This study aimed to assess the level of curriculum implementation, evaluate the level of physical infrastructure management, and investigate the influence of physical infrastructure management in the areas of lecture room facilities, technology facilities and safety devices on curriculum implementation in public universities in Northern Uganda. The study employed a positivist approach. The sample consisted of 123 academic staff selected using a simple random sampling technique. Data was collected using a self-administered questionnaire and analysed using frequencies,percentages and means at the descriptive level, correlations at the bivariate level, and multiple linear regression at the multivariate level. The results showed that the level of curriculum implementation was low and the level of physical infrastructure management was moderate. Also, lecture room facilities had a significant positive influence on curriculum implementation. However, technology facilities and safety devices had a positive but insignificant influence on curriculum implementation. Therefore, it was concluded that physical infrastructure management, concentrating on lecture room facilities, technology equipment and safety devices, is vital for curriculum implementation in public universities. Thus, this study recommended that the government and public universities should make deliberate efforts to provide sufficient lecture room facilities, modern technology equipment and sufficient safety devices to further improve curriculum implementation, especially in activities such as preparation for teaching, content delivery and assessment of learning in the public universities.