This study examined the influence of job satisfaction on organisational commitment of full-time academic staff of Kyambogo University, Uganda. Specifically, the study examined the influence of intrinsic and extrinsic job satisfaction on organisational commitment of full-time academic staff. Basing on the conceptualisation by Allen and Meyer (1990), organisational commitment was studied in terms of affective, continuance and normative commitment. Using the quantitative approach for inferential analysis, the study adopted the cross-sectional research design on a sample of 175 fulltime academic staff. The researcher used a self-administered questionnaire to collect the data. Data analysis involved carrying out structural equation modelling (SEM) using SmartPLS. The results indicated that while intrinsic job satisfaction positively and significantly influenced organisational commitment among full-time academic staff, extrinsic job satisfaction had a negative and insignificant influence on their organisational commitment. The study concluded that while intrinsic job satisfaction is imperative for organisational commitment of academic staff, extrinsic job satisfaction did not. Therefore, it was recommended that to boost academic staff members’ organisational commitment, university managers should promote their intrinsic satisfaction more than extrinsic job satisfaction.