The study aimed at university sustainability development and the management of academic staff in Uganda. The sample comprised 80 respondents, including the teachers, heads of department and top managers in the universities. Data was analysed using one-way ANOVA by way of Excel statistical data analysis. Qualitative data was analysed using descriptions in themes deciphered in the course of the study. The majority of the academic staff lacked adequate knowledge about what was required of them in connection with university sustainability development. There was a significant relationship between university sustainability development and the management of academic staff in Uganda. It was concluded that many universities do not promote cross-campus collaborations that connect campus administration and students, which has resulted in inadequacy of funds to sufficiently train and manage staff. The study concluded that the majority of universities are still young in their sustainability effort of fully engaging the academic staff in a number of planned activities. It was also concluded that the majority of the academic staff are hesitant to get involved in university sustainability development due to lack of equity accorded to some of the staff. There is need to strengthen training of the academic staff in all areas that the universities feel are appropriate in order to greatly maintain and boost its sustainability development. There is also need to encourage a bottom-top approach for effective and sufficient communication and to provide appropriate and well-informed criteria to everyone on the mechanism used to reward the best academic staff as a way of increasing the positive impact of university sustainability development.